526 InhibigenTM-specific responses suppress anti-tumor immunity and promote tumor growth
نویسندگان
چکیده
منابع مشابه
Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity
In patients with cancer, the wasting syndrome, cachexia, is associated with caloric deficiency. Here, we describe tumor-induced alterations of the host metabolic response to caloric deficiency that cause intratumoral immune suppression. In pre-cachectic mice with transplanted colorectal cancer or autochthonous pancreatic ductal adenocarcinoma (PDA), we find that IL-6 reduces the hepatic ketogen...
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In Response: We appreciate Yoon and colleagues’ interest in our report and welcome the opportunity to reply to their comments. Our study was designed in a context in which several clinical trials, including patients with head and neck squamous cell carcinomas, breast cancer, non–small cell lung cancer and nonmyeloid malignancies, showed a potential deleterious effect of recombinant human erythr...
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Altered DNA methylation is a hallmark of cancer genomes and has been advocated as both a marker and mechanism of the malignant phenotype. In the conventional view, such alterations include global DNA hypomethylation, linked to aberrant expression of oncogenic driver genes and more localised de novo hypermethylation at ‘CpG-island’ promoters, argued to cause inappropriate silencing of tumor supp...
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BACKGROUND AND OBJECTIVES Photodynamic therapy (PDT) efficacy appears to be enhanced in the presence of an intact immune system and PDT has been shown to augment anti-tumor immunity. The mechanisms leading to the enhancement of the host immune response to tumor are unclear. Anti-tumor immunity depends upon the presence of activated antigen presenting cells (APCs). These cells are activated by t...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2020
ISSN: 2051-1426
DOI: 10.1136/jitc-2020-sitc2020.0526